Printed in the USA. To evaluate the long-term failure patterns in patients who underwent an In-capromab pendetide ProstaScint scan as part of their pretreatment assessment for a rising prostate-specific antigen PSA level after prostatectomy and subsequently received local radiotherapy RT to the prostate bed. Fifty-eight patients were referred for evaluation of a rising PSA level after radical prostatectomy.
Overview The ProstaScint scan, also known as the prostate-specific membrane antigen PSMA study, is used to help your doctor identify the spread of prostate cancer.
It can help determine if you have advanced cancer or a cancer that has metastasized or spread to soft tissue beyond your prostate. Keep reading to learn more about this procedure. ProstaScint scans may be more accurate in people with a higher risk for metastatic cancer. The scan is not recommended in people who are at a low risk for metastasis because of the potential for false positive test results.
Your doctor will usually estimate your risk of metastasis using a number of factors and, based on your risk level, determine if a ProstaScint scan is recommended. While a ProstaScint scan is not recommended to measure the effectiveness of a treatment, there are circumstances in which it will be used after treatment has begun.
A prostatectomy is surgery to remove all or part of the prostate gland. Preparing for the procedure A ProstaScint scan will usually take two to three visits.
The scan is done at a nuclear imaging center. The day before your final scan, however, your doctor might ask that you follow a clear liquid diet and drink magnesium citrate, a laxative. Insurance coverage of the ProstaScint scan varies, but the majority of insurance companies and Medicare cover the procedure.
The mixture contains a protein that has a radioactive molecule — the isotope Indium — linked to it. The protein specifically attaches to prostate cancer cells so that a radiological camera can detect only those cells.
That will allow the isotope to clear from the rest of your body. Each scan will last between one and three hours. The scans use a single-photon emission computed tomography SPECT machine to detect the radioactive isotope attached to cancer cells.
Sometimes, a ProstaScint scan is done together with a technetiumm-labeled red blood cell scan. That scan helps to visualize blood vessels around the prostate gland by a similar method of detecting radioactivity. This is more expensive, but more precise. After your scans are finished, a radiologist will interpret the images and send the results and findings to your doctor.
The ProstaScint scan usually does not cause adverse reactions and meets radiation safety standards. It was approved by the U. Food and Drug Administration in The availability of specific imaging probes is the nuclear fuel for molecular imaging by positron emission tomography and single-photon emission computed tomography.
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The primary objective of this overview is to apprise clinical urologists and oncologists of the current state of fused multimodality imaging of prostate cancer, which can be applied to optimize treatment by ensuring that a patient's disease is characterized as well as current imaging technology permits.
Conventional imaging studies (e.g., MRI and CT) rarely demonstrate measurable disease upon relapse in the setting of low ( ng/ml) serum PSA levels, and, therefore, molecular imaging studies such as ProstaScint might play a role in detecting local recurrence.
EUSA Pharma announced that PROSTASCINT® (capromab pendetide) fusion imaging was shown to effectively guide prostate cancer therapy targeting and dosing and is a significant predictor of disease.
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